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Abstract #4416

Mapping mean axon diameters using diffusion MRI with oscillating gradients

Junzhong Xu 1 , Hua Li 1 , Kevin D Harkins 1 , Jingping Xie 1 , Mark D Does 1 , and John C Gore 1

1 Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States

Due to relatively long diffusion times used, small axons are usually overestimated using PGSE-based models. In the current study, the OGSE method was implemented in fixed spinal cord measurements with much shorter effective diffusion times to enhance detection sensitivity to small axons. The results show that the fitted mean axon diameters are in very good agreement with histology.

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