Fast and robust measurement of microstructural dimensions using temporal diffusion spectroscopy

Current PGSE-based approaches usually require long scanning times and high q-values to detect small axons, which are limited by the long diffusion times and the significantly reduced sensitivity to small spatial scales. OGSE has been shown to achieve much shorter diffusion times and hence may be able to detect smaller axons with high sensitivity. We measure the inner diameters of hollow microcapillaries using OGSE methods. Two ADC values are sufficient to extract the cylinder diameters accurately. OGSE is insensitive to the intrinsic diffusion coefficient in the relatively low frequency range. We propose OGSE as a fast and robust method for mapping axon sizes non-invasively.

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