Abstract #4418
Axon diameter distribution (ADD) mapping of porcine spinal cord using d-PFG MRI
Dan Benjamini 1,2 , Michal E Komlosh 1,3 , Uri Nevo 2 , and Peter J Basser 1
1
NIH, Bethesda, MD, United States,
2
Tel
Aviv University, Tel Aviv, Israel,
3
USUHS,
Bethesda, MD, United States
Noninvasive estimation of a non-parametric axon diameter
distribution (ADD) provides sub-voxel microstructural
information of white matter tissue. ADD infers on the
nerve conductivity, and is influenced by several
diseases, such as amyotrophic lateral sclerosis and
multiple sclerosis. A recently suggested 2D double
pulsed-field gradient MRI experiment is used on a
porcine spinal cord. A voxel-by-voxel non-parametric ADD
estimation provides a sub-voxel resolution map. Distinct
domains where the ADDs are similar are then found. ADD
estimation might prove to have clinical MRI applications
owing to its critical functional role in the central and
peripheral nervous systems, in normal and abnormal
tissue.
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