Abstract #0129
Combined T 1 and T 2 Measurement for Non-Invasive Evaluation of Blood Oxygen Saturation and Hematocrit
Sharon Portnoy 1 , Mike Seed 2 , Julia Zhu 2 , John G. Sled 1,3 , and Christopher K. Macgowan 1,4
1
Department of Medical Biophysics, University
of Toronto, Toronto, Ontario, Canada,
2
Diagnostic
Imaging, The Hospital for Sick Children, University of
Toronto, Toronto, Ontario, Canada,
3
Mouse
Imaging Centre, The Hospital for Sick Children, Toronto,
Ontario, Canada,
4
Diagnostic
Imaging, The Hospital for Sick Children, Toronto,
Ontario, Canada
We seek to establish whether a combination of vascular T
1
and
T
2
relaxometry
measurements can be reliably used to determine both
oxygen saturation,
sO
2
,
and hematocrit,
Hct
.
This is in contrast to typical vascular oximetry methods
which use a single T
2
measurement
to compute
sO
2
only,
while assuming a normal value for
Hct
.
Knowledge of
Hct
is
highly valuable in our population of interest: fetuses
potentially affected by hypoxia. Results on
in-vitro
blood
samples indicate that, in general, combining T
1
and
T
2
data
improves the accuracy of
sO
2
estimation
and provides a reliable means for determining
Hct
.
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