Abstract #0160
Hyperpolarized gas MR diffusion simulations and experiments in realistic 3D models and phantoms of human acinar airways
Juan Parra-Robles 1 , Bart Veeckmans 2 , Madhwesha Rao 1 , James C Hogg 3 , and Jim M Wild 1
1
University of Sheffield, Sheffield, South
Yorkshire, United Kingdom,
2
Materialise,
Leuven, Belgium,
3
University
of British Columbia, Vancouver, British Columbia, Canada
The validity of current theoretical models of
hyperpolarized gas MR diffusion used to quantify lung
microstructure is limited by their use of simplified
geometries. This work describes de development of
realistic geometric models of human lung microstructure
based on micro-CT images of excised lung samples. These
models are used in numerical simulations of gas MR
diffusion and to create realistic phantoms by 3D
printing, which are used in
3
He
MR experiments to validate modelling results. These
models and phantoms provide a new simulation and
experimental framework to develop new MR methods and
theoretical models to study lung anatomy and physiology.
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