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Abstract #0161

Changes in White-matter Integrity and Evoked fMRI Responses in Chronic Hypertension

Yunxia Li 1,2 , Qian Wang 1 , Qiang Shen 1 , Shiliang Huang 1 , Lora Talley Watts 1 , and Timothy Q Duong 1

1 Research Imaging Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 2 Department of Neurology, Tongji Hospital, Tongji University, Shanghai, China

Chronic hypertension increases susceptibility to neurological disorders. The goal of this study was to evaluate cerebral blood flow (CBF) and cerebrovascular reactivity (CR) in response to hypercapnia in an established rat model of hypertension (SHR) at different stages of the disease progression. Comparisons were made with age-matched normotensive Wistar Kyoto (WKY) rats. CBF and CR were altered in early stage of chronic hypertension and worsen with disease progression, ultimately resulting in hypoperfusion and compromised cerebrovascular reserve. MRI has the potential to be used to identify brain regions susceptible to hemodynamic compromise, improve understanding of disease pathogenesis, guider treatments in hypertension.

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