Abstract #0162
Multi-modality 4D Stroke Template for the Characterization of Arterial Ischemic Stroke Evolution Over Time
Samantha J Ma 1 , David S Liebeskind 1 , Songlin Yu 1 , Holly Wilhalme 2 , David Elashoff 2 , Xin J Qiao 3 , Nerses Sanossian 1 , Sidney Starkman 1,4 , Latisha K Ali 1 , Fabien Scalzo 1 , Bryan Yoo 3 , Jeffrey L Saver 1 , Noriko Salamon 3 , and Danny JJ Wang 1
1
Neurology, UCLA, Los Angeles, CA, United
States,
2
Medicine
Statistics Core, UCLA, Los Angeles, CA, United States,
3
Radiology,
UCLA, Los Angeles, CA, United States,
4
Emergency
Medicine, UCLA, Los Angeles, CA, United States
Serial neuroimaging that includes both pre- and
post-therapy time points provides insight on the
dynamics of reperfusion and may be useful in the
guidance of further interventions. Here we demonstrate
that a multi-modal four-dimensional ischemic stroke
template of middle cerebral artery (MCA) stroke can be
used to characterize the effects of thrombolytic
intervention over time as ischemic brain tissue makes
the transition from injury into repair. As the injured
brain tissue evolves with time, there is clear evidence
that treatment induces a significant hyperemic response
in hypoperfused regions. By contrast, tissue that is
left untreated exhibits incomplete reperfusion.
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