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Abstract #0162

Multi-modality 4D Stroke Template for the Characterization of Arterial Ischemic Stroke Evolution Over Time

Samantha J Ma 1 , David S Liebeskind 1 , Songlin Yu 1 , Holly Wilhalme 2 , David Elashoff 2 , Xin J Qiao 3 , Nerses Sanossian 1 , Sidney Starkman 1,4 , Latisha K Ali 1 , Fabien Scalzo 1 , Bryan Yoo 3 , Jeffrey L Saver 1 , Noriko Salamon 3 , and Danny JJ Wang 1

1 Neurology, UCLA, Los Angeles, CA, United States, 2 Medicine Statistics Core, UCLA, Los Angeles, CA, United States, 3 Radiology, UCLA, Los Angeles, CA, United States, 4 Emergency Medicine, UCLA, Los Angeles, CA, United States

Serial neuroimaging that includes both pre- and post-therapy time points provides insight on the dynamics of reperfusion and may be useful in the guidance of further interventions. Here we demonstrate that a multi-modal four-dimensional ischemic stroke template of middle cerebral artery (MCA) stroke can be used to characterize the effects of thrombolytic intervention over time as ischemic brain tissue makes the transition from injury into repair. As the injured brain tissue evolves with time, there is clear evidence that treatment induces a significant hyperemic response in hypoperfused regions. By contrast, tissue that is left untreated exhibits incomplete reperfusion.

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