Abstract #0163
Variations in cerebral haemodynamics and capillary transit time heterogeneity in patients before and after carotid endarterectomy
Amit Mehndiratta 1,2 , Chang Sub Park 2 , David E Crane 3 , Ediri Sideso 4 , James Kennedy 5 , Bradley J MacIntosh 3 , Stephen J Payne 2 , and Michael A Chappell 2
1
CBME, Indian Institute of Technology Delhi,
New Delhi, Delhi, India,
2
IBME,
University of Oxford, Oxford, Oxfordshire, United
Kingdom,
3
Medical
Biophysics, Sunnybrook Research Institute, Toronto, ON,
Canada,
4
Nuffield
Department of Surgery, University of Oxford, Oxford,
Oxfordshire, United Kingdom,
5
Acute
Vascular Imaging Centre, Radcliffe Department of
Medicine, University of Oxford, Oxford, Oxfordshire,
United Kingdom
Reliable estimation of capillary transit time
distribution (TTD) and transit time heterogeneity (CTH)
has been questioned in literature. With CPI it is
possible to evaluate the variations in TTD in vivo. The
results from our analysis in 17 patients with carotid
atherosclerotic disease imaged both before and after CEA
showed that under the currently used standard DSC-MRI
imaging protocol more than 80% of the pathophysiological
variability in the data can be explained with only one
component.
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