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Abstract #0163

Variations in cerebral haemodynamics and capillary transit time heterogeneity in patients before and after carotid endarterectomy

Amit Mehndiratta 1,2 , Chang Sub Park 2 , David E Crane 3 , Ediri Sideso 4 , James Kennedy 5 , Bradley J MacIntosh 3 , Stephen J Payne 2 , and Michael A Chappell 2

1 CBME, Indian Institute of Technology Delhi, New Delhi, Delhi, India, 2 IBME, University of Oxford, Oxford, Oxfordshire, United Kingdom, 3 Medical Biophysics, Sunnybrook Research Institute, Toronto, ON, Canada, 4 Nuffield Department of Surgery, University of Oxford, Oxford, Oxfordshire, United Kingdom, 5 Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom

Reliable estimation of capillary transit time distribution (TTD) and transit time heterogeneity (CTH) has been questioned in literature. With CPI it is possible to evaluate the variations in TTD in vivo. The results from our analysis in 17 patients with carotid atherosclerotic disease imaged both before and after CEA showed that under the currently used standard DSC-MRI imaging protocol more than 80% of the pathophysiological variability in the data can be explained with only one component.

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