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Abstract #0164

A multi-parametric investigation of vascular alterations in elderly with hypertension

Min Sheng 1 , Kevin S. King 2 , Adam Sheffield 3 , Harshan Ravi 1 , Shin-Lei Peng 1 , Peiying Liu 1 , Zohre German 4 , and Hanzhang Lu 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2 Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 3 Medical program, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 4 Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States

Hypertension is a major risk factor for stroke, dementia, and cognitive decline. In order to investigate more sensitive biomarker of vascular dysfunction in the brain, we conducted a multiparametric investigation of hemodynamic changes in hypertension, including cerebral blood flow (CBF), venous cerebral blood volume (vCBV), venous oxygenation (Yv), and cerebrovascular reactivity (CVR) to CO2. In this study, we found that CBF and Yv increased with blood pressure while CVR decreased with blood pressure in elderly subjects. vCBV did not show any difference in hypertension. These vascular markers may precede structural changes of the brain and clinical symptoms.

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