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Abstract #0166

Postischemic Hyperperfusion on Arterial Spin Labeled Perfusion MRI is Linked to Hemorrhagic Transformation in Stroke

Songlin Yu 1 , David S Liebeskind 1 , Sumit Dua 2 , Holly Wilhalme 3 , David Elashoff 3 , Xin J Qiao 2 , Jeffry R Alger 1,2 , Nerses Sanossian 1 , Sidney Starkman 1,4 , Latisha K Ali 1 , Fabien Scalzo 1 , Xin Lou 1,5 , Jeffrey L Saver 1 , Noriko Salamon 2 , and Danny J.J. Wang 1,2

1 Neurology, UCLA, Los Angeles, CA, United States, 2 Radiology, UCLA, Los Angeles, CA, United States, 3 Medicine Statistics Core, UCLA, Los Angeles, CA, United States, 4 Emergency Medicine, UCLA, Los Angeles, CA, United States, 5 Radiology, Chinese Peoples Liberation Army (PLA) General Hospital, Beijing, China

The study investigated the relationship between postischemic hyperperfusion on arterial spin labeled (ASL) and hemorrhagic transformation (HT). 361 ASL scans were collected from 221 acute ischemic stroke patients (AIS). Hyperperfusion was more frequently detected post-treatment. Having hyperperfusion at any time point related significantly to HT (OR=3.5, 95%CI 2.0-6.3, P<0.001). There was a trend that patients with first hyperperfusion after 12 hours from stroke onset were more likely to experience severe HT than those with first hyperperfusion within 12 hours (Fisher's exact p-value = 0.06). ASL hyperperfusion may provide an imaging marker of HT and guide the management of AIS patients.

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