Abstract #0252
In vivo diffusion MR study at 7T of hindlimb muscles in a mouse model of Duchenne muscular dystrophy
Paola Porcari 1 , Elizabeth Greally 2 , Volker Straub 2 , and Andrew M Blamire 1
1
Newcastle Magnetic Resonance Centre,
Newcastle University, Newcastle upon Tyne, Tyne and
Wear, United Kingdom,
2
Institute
of Genetic Medicine, Newcastle University, Newcastle
upon Tyne, Tyne and Wear, United Kingdom
In this study, we investigated whether diffusion MRI
might be a useful method to evaluate differences in the
microarchitecture of hindlimb muscles between dystrophic
(mdx) and healthy (wt) mice of three groups of age. Mice
were investigated at multiple diffusion times and
significant differences between the diffusion properties
of hindlimb muscles in healthy and diseased mice were
found for long diffusion times. High specificity and
sensitivity of the method was demonstrated and also
confirmed by the preliminary results of the histological
assessment, thus suggesting a powerful and
straightforward application on humans.
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