Abstract #0253
The relationship of walking speed metrics to phosphorus magnetic resonance spectroscopy ( 31 P-MRS) bioenergetic measurements in the Baltimore Longitudinal Study of Aging (BLSA)
Seongjin Choi 1 , David A. Reiter 2 , Kenneth W. Fishbein 2 , Eleanor M. Simonsick 1 , Richard G. Spencer 2 , and Luigi Ferrucci 3
1
Translational Gerontology Branch,
NIH/National Institute on Aging, Baltimore, Maryland,
United States,
2
Laboratory
of Clinical Investigation, NIH/National Institute on
Aging, Baltimore, Maryland, United States,
3
Intramural
Research Program, NIH/National Institute on Aging,
Baltimore, Maryland, United States
Gait speed is an important predictor of morbidity in the
elderly and skeletal muscle mitochondrial function plays
a central role in mobility.
31
P
MRS of skeletal muscle permits evaluation of
mitochondrial function through the phosphocreatine
recovery rate (k
PCr
) after exercise. In this
cross-sectional study using the Baltimore Longitudinal
Study of Aging cohort we assessed associations between
31
P
MRS-determined mitochondrial function, age and four
walking speed metrics. We found that k
PCr
, a
marker of mitochondrial synthetic capacity, had the
strongest correlation with 400 m walk performance at
maximum pace, which was the most strenuous ambulatory
exercise among the four walking metrics.
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