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Abstract #0277

Diffusion Sensitivity of 3D-GRASE in ASL Perfusion

Xiang He 1 , Thang Le 2 , Hoi-Chung Leung 2 , Parsey Ramin 3 , and Mark Schweitzer 1

1 Department of Radiology, Stony Brook University, Stony Brook, New York, United States, 2 Department of Psychology, Stony Brook University, New York, United States, 3 Department of Psychiatry, Stony Brook University, New York, United States

The diffusion sensitivity of ASL perfusion quantification with 3D-GRASE readout is investigated on human volunteer subjects. The results demonstrated a robust under-estimation on gray matter perfusion and significant over-estimation on white matter perfusion, especially in sub-cortical white matter. The diffusion sensitivity of intravascular ASL water signal is proposed as the root cause of the observed artifacts. This study suggests that high segmentation factor acquisition scheme, i.e. 6 or 8 shot (3PR 2PE or 4PAR 2PE), should be applied in GRASE or RARE readout to reduce the diffusion artifacts.

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