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Abstract #0278

Comparison of Cerebral Blood Flow and Arterial Transit Time mapping methods: Look-Locker ASL, Hadamard Encoded ASL, and Multi-TI ASL with Variable Bolus and TR

Megan Johnston 1 and Youngkyoo Jung 1,2

1 Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States, 2 Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States

Multi-TI ASL with Variable bolus and TR ASL uses variable post-labeling delays to enable simultaneous arterial transit time and cerebral blood flow estimation. Time efficiency is improved by shortening TR for shorter TI times. Shortened labeling bolus durations allow for shortened TI times which enables for T1 and M0 estimation from the same raw data, fitting to the saturation recovery equation. Resulting blood flow and transit time maps fit the perfusion model better in the gray matter than Hadamard Encoded ASL and Look-Locker ASL with a larger percentage of voxels having a significant fit to the kinetic model.

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