Abstract #0443
Fast dynamic measurements of T 1 relaxation times: influence and correction of T 2 * effects
Olaf Dietrich 1 , Maximilian Freiermuth 1 , Linus Willerding 2 , Michael Peller 1 , and Maximilian F Reiser 1
1
Josef Lissner Laboratory for Biomedical
Imaging, Institute for Clinical Radiology, LMU Ludwig
Maximilian University of Munich, Munich, Germany,
2
Department
of Internal Medicine III, LMU Ludwig Maximilian
University of Munich, Munich, Germany
The purpose of this study was to analyze and correct the
influence of contrast-agent induced T2* (transverse)
relaxation effects on the accuracy of fast dynamic 3D
gradient-echo T1 measurements with a combined
variable-flip-angle baseline measurement and subsequent
single-flip-angle measurements during the dynamic phase.
Previously proposed techniques for T1 quantitation
neglect the influence of transverse relaxation effects
on the measured signal during the dynamic phase and
result in systematically increased T1 values. We
demonstrate that the influence of transverse relaxation
can be expressed as a function of T1 leading to an
implicit expression for T1 that can be solved
numerically.
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