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Abstract #0444

B 0 Correction for Myelin Water Fraction Imaging Based on Multi-Slice MGRE Acquisitions

Eva Alonso Ortiz 1 , Ives R. Levesque 2,3 , and G. Bruce Pike 4

1 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, 2 Medical Physics Unit, Department of Oncology, McGill University, Montreal, Quebec, Canada, 3 Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada, 4 Department of Radiology and Hotchkiss Brain Institute, University of Calgary, Alberta, Canada

Myelin water fraction (MWF) imaging based on multi-component (MC) T2 analysis can be used to quantitatively assess myelin. Recently, multi-gradient echo (MGRE) sequences have been proposed for MCT2*-based MWF mapping, due to their fast, whole-brain or multi-slice imaging capability, low specific absorption rate (SAR) and short echo spacing (ES). An important caveat for MGRE imaging is the significant signal loss caused by magnetic field inhomogeneities (ΔB0), making proper ΔB0 correction necessary in order to avoid inaccuracies in MWF maps. We propose a ΔB0 correction method based on partial fits to MGRE data obtained for the MWF-mapping itself.

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