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Abstract #0467

Assessment of renal allograft fibrosis with magnetic resonance elastography in kidney transplantation patients

Nan Jiang 1 , General Leung 2,3 , Serge Jothy 4 , Darren A. Yuen 3,5 , and Anish Kirpalani 2,3

1 Faculty of Medicine, University of Toronto, Toronto, ON, Canada, 2 Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada, 3 Keenan Research Centre, St. Michael's Hospital, Toronto, ON, Canada, 4 Department of Pathology, St. Michael's Hospital, Toronto, ON, Canada, 5 Division of Nephrology, St. Michael's Hospital, Toronto, ON, Canada

Chronic allograft injury (CAI) is a devastating outcome affecting 60% of kidney transplant patients at 10 years. Fibrosis is the common pathway leading to CAI. We compared stiffness values measured by MR elastography (MRE) in renal allografts to fibrosis measured by biopsy, In our pilot study of 8 patients, we found significant increase in MRE-derived stiffness in allografts with severe fibrosis compared to no, minimal, mild fibrosis and moderate fibrosis. MRE may enable non-invasive quantitative assessment of renal allograft fibrosis and may be able to predict sites for targeted biopsy.

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