Abstract #0642
In-utero localized diffusion MRI of the embryonic mouse brain microstructure and injury
Dan Wu 1 , Jun Lei 2 , Jason Rosenzweig 2 , Irina Burd 2 , and Jiangyang Zhang 3
1
Biomedical Engineering, Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States,
2
Gynecology
and Obstetrics, Johns Hopkins University School of
Medicine, Maryland, United States,
3
Radiology,
Johns Hopkins University School of Medicine, Maryland,
United States
In vivo diffusion MRI (dMRI) of the embryonic mouse
brain is extremely challenging due to the complex motion
and the demand for high-resolution to resolve the early
brain microstructures. We proposed a localized imaging
technique to achieve 3D dMRI in a reduced field-of-view,
using spatially selective excitation pulses. Motion was
reduced with the fast imaging, and further corrected by
navigator echoes and retrospective registration. We were
able to delineate major white and gray matter structures
in the normal at 0.2 mm isotropic resolution, and detect
embryonic brain injury in a mouse model of intrauterine
inflammation.
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