Meeting Banner
Abstract #0643

Longitudinal in utero characterization of cerebral cortical surface area, curvature and fractional anisotropy in the rhesus monkey

Xiaojie Wang 1 , Colin Studholme 2 , and Christopher D. Kroenke 1

1 Oregon Health & Science University, Portland, Oregon, United States, 2 University of Washington, Seattle, Washington, United States

Longitudinal in utero MRI was performed on monkey fetuses at gestation days 85, 110, and 135. High resolution T2-weighted volumes and fractional anisotropy (FA) volumes were reconstructed from multiple sets of turbo-spin-echo acquired T2W and spin-echo EPI acquired DWIs. Cerebral cortical surface area (SA), curvature and FA were computed using CARET software. Curvature and SA increase while FA decreases with gestation age. Analysis of changes in FA, SA, and surface curvature revealed that morphological differentiation of cerebral cortical neurons, thought to underlie FA changes, correlates with changes in cortical curvature but not surface area.

This abstract and the presentation materials are available to members only; a login is required.

Join Here