Abstract #0643
Longitudinal in utero characterization of cerebral cortical surface area, curvature and fractional anisotropy in the rhesus monkey
Xiaojie Wang 1 , Colin Studholme 2 , and Christopher D. Kroenke 1
1
Oregon Health & Science University,
Portland, Oregon, United States,
2
University
of Washington, Seattle, Washington, United States
Longitudinal in utero MRI was performed on monkey
fetuses at gestation days 85, 110, and 135. High
resolution T2-weighted volumes and fractional anisotropy
(FA) volumes were reconstructed from multiple sets of
turbo-spin-echo acquired T2W and spin-echo EPI acquired
DWIs. Cerebral cortical surface area (SA), curvature and
FA were computed using CARET software. Curvature and SA
increase while FA decreases with gestation age. Analysis
of changes in FA, SA, and surface curvature revealed
that morphological differentiation of cerebral cortical
neurons, thought to underlie FA changes, correlates with
changes in cortical curvature but not surface area.
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