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Abstract #0763

In-vivo proton MR spectroscopic imaging of the human brain gliomas at 9.4 Tesla: evaluation of metabolite coordinates

Grzegorz L. Chadzynski 1,2 , Gisela Hagberg 1,2 , Jonas Bause 2 , G. Shajan 2 , Sotirios Bisdas 3 , Rolf Pohmann 2 , and Klaus Scheffler 1,2

1 Dept. Biomedical Magnetic Resonance, University of Tuebingen, Tuebingen, Germany, 2 Dept. High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 3 Dept. Diagnostic and Interventional Neuroradiology, University of Tuebingen, Tuebingen, Germany

Recently it was demonstrated that the advantages of ultra-high field MR spectroscopic imaging (MRSI), namely the better signal-to-noise ratio and the improved spectral resolution, can be useful in clinical applications. Studies conducted at lower field strengths (below 3T) have shown that an evaluation with the Orthonormal Discriminant Vector method (ODV) enables differentiation between low (WHO grade II and III) and high grade (WHO grade IV) human brain tumors. The aim of this study was to verify the usefulness of the ODV method in assessing human brain tumor spectra measured with MRSI at a field strength of 9.4T.

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