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Abstract #0765

Giant Intracranial Aneurysms at 7 Tesla MRI: A New Diagnostic Approach to Understand This Rare Intracranial Vascular Pathology

Bixia Chen 1,2 , Toshinori Matsushige 2,3 , Stefan Maderwald 1 , Sren Johst 1 , Harald H. Quick 1,4 , Mark Edward Ladd 1,5 , Ulrich Sure 2 , and Karsten Henning Wrede 1,2

1 Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, NRW, Germany, 2 Department of Neurosurgery, University Hospital Essen, University Duisburg-Essen, Essen, NRW, Germany, 3 Department of Neurosurgery, Hiroshima University Hospital, Hiroshima University, Hiroshima, Hiroshima Prefecture, Japan, 4 High Field and Hybrid MR Imaging, University Hospital Essen, University Duisburg-Essen, Essen, NRW, Germany, 5 Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, BW, Germany

Intracranial giant aneurysms (IGA) were prospectively analyzed at 7T MRI, focusing on the aneurysm wall. Six patients were examined in a 7T whole-body MR scanner with a 32-channel head coil. TOF, MPRAGE, and SWI sequences were acquired. Two surgically resected aneurysms were suitable for histological examination. 7T TOF and SWI could precisely reveal microstructures and iron deposition in individual layers of the aneurysm wall as seen in histopathology. Measurement of wall thickness on 7T TOF corresponded best with histopathological findings. Ultra-high-field MRI of this rare intracranial vascular pathology can contribute to understanding the complex pathophysiology of aneurysm growth and rupture.

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