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Abstract #0795

Assessing relationship between intracranial vascular compliance and aortic pulse wave velocity using MRI

Lirong Yan 1 , Collin Liu 2 , Robert Smith 1 , Mayank Jog 1 , Kate Krasileva 1 , Cheng Li 3 , Michael Langham 3 , and Danny JJ Wang 1

1 Neurology, University of California Los Angeles, Los Angeles, CA, United States, 2 University of Southern California, CA, United States, 3 University of Pennsylvania, Philadelphia, PA, United States

The purpose of this study was to investigate the relationship between intracranial vascular compliance and aortic pulse wave velocity (PWV) in a cohort of subjects with mixed vascular risks. We found there was significant negative correlation between intracranial VC and aortic PWV. Subjects with high vascular risks showed reduced intracranial VC and elevated aortic PWV compared to subjects with low vascular risks. These findings suggest that changes in vascular compliance typically extend from aorta to intracranial vessels.

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