Abstract #0796
Validation of dual-injection dynamic susceptibility contrast perfusion weighted imaging against pseudo-continuous arterial spin labeling: a pilot study
Natalie M Wiseman 1 , Meng Li 2 , Mahmoud Zeydabadinezhad 3 , Jessy Mouannes-Srour 3 , Yongquan Ye 2 , E. Mark Haacke 2,3 , and Zhifeng Kou 2,3
1
Department of Psychiatry and Behavioral
Neurosciences, Wayne State University School of
Medicine, Detroit, MI, United States,
2
Department
of Radiology, Wayne State University School of Medicine,
Detroit, MI, United States,
3
Department
of Biomedical Engineering, Wayne State University,
Detroit, MI, United States
DSC-PWI suffers from blooming, clipping, and saturation
effects in large vessels, which make arterial input
function (AIF) determination unreliable. To combat this,
we used a dual-injection method in which 1/6 of the
contrast dose is used to determine the AIF and the
remaining 5/6 is used to visualize perfusion in brain
tissue. We compared these CBF measurements to
pseudo-continuous ASL (pCASL) CBF measurements. The
correlation coefficients of 0.85 and 0.63 show good
correlation in large ROIs and slightly less good
correlation in the small ROIs, respectively. In
conclusion, the dual-injection DSC-PWI method provides a
reliable, high resolution measurement of CBF.
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