The acute effects of metformin on cardiac and hepatic metabolism: a hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopy study
Andrew Lewis 1 , Chloe McCallum 1 , Jack Miller 1,2 , Lisa Heather 1 , and Damian J Tyler 1
Department of Physiology, Anatomy and
Genetics, University of Oxford, Oxford, United Kingdom,
of Physics, University of Oxford, Oxford, United Kingdom
The mechanism of action of metformin in type II diabetes
is uncertain, but may involve altered cellular redox
state and carbohydrate metabolism. We used
hyperpolarized [1-13C]pyruvate magnetic resonance
spectroscopy to investigate the acute effects of a
metformin infusion upon cardiac and hepatic metabolism
in Wistar rats (n=6-7 per group). An infusion of 50mg
metformin increased the cardiac [1-13C]lactate to
[1-13C]pyruvate ratio compared to a control infusion
(P<0.05), without affecting pyruvate dehydrogenase flux.
These findings suggest an increase in the size of the
cardiac lactate pool and/or increased lactate
dehydrogenase activity, demonstrating that metformin has
previously unknown effects upon cardiac metabolism.
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