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Abstract #0802

Fructose increases de novo lipogenesis in the liver of rats: an in vivo 1 H-[ 13 C] MRS study

Sharon Janssens 1 , Klaas Nicolay 1 , and Jeanine J. Prompers 1

1 Biomedical NMR, Eindhoven University of Technology, Eindhoven, Noord-Brabant, Netherlands

Excessive consumption of sugars in caloric sweetened beverages causes hepatic steatosis, which is attributed to de novo lipogenesis. In this study we implemented a non-invasive method for the direct in vivo measurement of de novo lipogenesis in the liver using localized 1 H MRS with 13 C editing to detect 13 C-labeled liver lipids after oral administration of [U- 13 C 6 ] glucose. Using this method we studied the effects of caloric and non-caloric sweeteners on liver lipid metabolism in rats. In contrast to glucose and aspartame, fructose increased liver lipid content, which was associated with an increased conversion of 13 C-labeled glucose to liver lipids.

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