Abstract #0802
Fructose increases de novo lipogenesis in the liver of rats: an in vivo 1 H-[ 13 C] MRS study
Sharon Janssens 1 , Klaas Nicolay 1 , and Jeanine J. Prompers 1
1
Biomedical NMR, Eindhoven University of
Technology, Eindhoven, Noord-Brabant, Netherlands
Excessive consumption of sugars in caloric sweetened
beverages causes hepatic steatosis, which is attributed
to
de novo
lipogenesis.
In this study we implemented a non-invasive method for
the direct
in
vivo
measurement
of
de novo
lipogenesis
in the liver using localized
1
H
MRS with
13
C
editing to detect
13
C-labeled
liver lipids after oral administration of [U-
13
C
6
]
glucose. Using this method we studied the effects of
caloric and non-caloric sweeteners on liver lipid
metabolism in rats. In contrast to glucose and
aspartame, fructose increased liver lipid content, which
was associated with an increased conversion of
13
C-labeled
glucose to liver lipids.
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