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Abstract #0996

Exploring a Flexible Pulse Design for Studying Magnetization Transfer

Peter van Gelderen 1 , Xu Jiang 1 , and Jeff H Duyn 1

1 AMRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States

Magnetization Transfer (MT) contrast is sensitive to brain myelination but lacks specificity, while quantification is difficult and requires lengthy experiments, including T1 measurement. Pulsed MT experiments may offer a simpler way to obtained quantitative measures, such as bound pool fraction and transfer rates. Here we explore a variation on a binominal pulse design for optimizing the pulsed MT experiment and demonstrate its application to study MT contrast in white matter.

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