Abstract #0996
Exploring a Flexible Pulse Design for Studying Magnetization Transfer
Peter van Gelderen 1 , Xu Jiang 1 , and Jeff H Duyn 1
1
AMRI, LFMI, NINDS, National Institutes of
Health, Bethesda, MD, United States
Magnetization Transfer (MT) contrast is sensitive to
brain myelination but lacks specificity, while
quantification is difficult and requires lengthy
experiments, including T1 measurement. Pulsed MT
experiments may offer a simpler way to obtained
quantitative measures, such as bound pool fraction and
transfer rates. Here we explore a variation on a
binominal pulse design for optimizing the pulsed MT
experiment and demonstrate its application to study MT
contrast in white matter.
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