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Abstract #1137

Quantitative DCE Analysis for Breast Imaging: The Benefit of Dixon Fat-Water Separation in an ultrafast TWIST-VIBE Protocol

Elisabeth Weiland 1 , Sandra Peter 2 , Dominik Nickel 1 , Rolf Janka 2 , Michael Uder 2 , and Evelyn Wenkel 2

1 MR Application Developement, Siemens Healthcare, Erlangen, Germany, 2 Radiology, University of Erlangen, Germany

We evaluated the potential of Dixon fat-water separation using an ultrafast view sharing DCE protocol to differentiate between benign and malignant lesions of very early contrast phases. Analysis of maximum slope (MS) and time-to-enhancement (TTE) of the kinetic curves were performed on water-only images for 37 mass lesions. Best differentiation was achieved with MS, derived from the water-only images (ROC analysis with area under curve of 0.914). Due to its short acquisition time and its robust image quality ultrafast dual-echo sequences with Dixon fat-water separation may be beneficial for MR-based breast screening.

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