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Abstract #1138

Alterations to breast tissue chemistry in women at risk of cancer: 2D MR spectroscopy in vivo study

Jessica Buck 1 , Saadallah Ramadan 1 , Leah Best 2 , Judith Silcock 3 , Jameen Arm 2 , Scott Quadrelli 1 , Gorane Santamaria 1 , Kin Men Leong 2 , Peter Lau 2 , Peter Malycha 1 , David Clark 1,3 , and Carolyn Mountford 1,4

1 Centre for MR in Health, University of Newcastle, Newcastle, NSW, Australia, 2 Calvary Mater Hospital, Newcastle, NSW, Australia, 3 The Breast and Endocrine Centre, Gateshead, NSW, Australia, 4 Centre for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

In vivo 2D L-COSY identifies premalignant changes in women at high risk of developing breast cancer that are not seen by routine imaging, and allows women to be identified as MR spectroscopy Low Risk or MR spectroscopy High Risk according to changes recorded. Changes in the MR spectroscopy High Risk group include deregulation of lipid pathways and increased levels of metabolites. If these changes are confirmed in larger populations, it is possible that this information will allow women at increased clinical risk for breast cancer an objective means to monitor changes that may be taking place in their breast tissue.

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