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Abstract #1139

Assessment of Background Parenchymal Enhancement in Breast MRI of BRCA 1/2 Mutation Carriers Compared to Matched Controls

Alana Amarosa Lewin 1 , Sungheon Kim 1 , James S Babb 1 , Amy N Melsaether 1 , Jason McKellop 1 , Melanie Moccaldi 2 , Ana Paula Klautau Leite 3 , and Linda Moy 1

1 Radiology, New York University School of Medicine, New York, New York, United States, 2 Radiology, New York University Cancer Institute, New York, New York, United States, 3 Radiology, Hospital das Clnicas, School of Medicine, University of So Paulo, Brazil

This study investigates whether quantitative kinetic analysis of benign lesions and background parenchyma (BP) in breast MRI can elucidate differences between BRCA carriers and sporadic controls with high risk for breast cancer. We identified 49 BRCA mutation carriers and 49 control cases with benign lesions for comparison of their initial and delayed enhancement ratios (IER and DER) of BP. The control group showed significant differences in IER and DER between pre and post-menopausal women, but the BRCA group did not. Our results also indicate that the BRCA gene mutation has multifactorial and complex clinical and biologic implications.

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