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Abstract #1140

A Practical Approach to Pharmacokinetic Modelling in monitoring Neoadjuvant Chemotherapy in Breast Cancer

Reem Bedair 1 , Andrew Patterson 2 , Mary McLean 3 , Roie Manavaki 1 , Scott Reid 4 , John Griffiths 3 , Martin Graves 2 , and Fiona Gilbert 1

1 University of Cambridge, Department of Radiology, Cambridge, Cambridgeshire, United Kingdom, 2 Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom, 3 Cancer Research UK Cambridge Research Institute, Cambridge, Cambridgeshire, United Kingdom, 4 GE Healthcare, Diagnostic Imaging, Buckingham, Buckinghamshire, United Kingdom

Quantitative DCE-MRI together with pharmacokinetic modelling enables the assessment of tumour-vessel permeability and leakage space in vivo. This work compares the early changes in the PK-derived parameter (Ktrans ) using both a voxel-wise histogram analysis across the entire tumour and the average Ktrans from the largest slice in cohort of breast cancer patients undergoing neoadjuvant chemotherapy. Although pixel-based analyses can demonstrate significant differences in the distribution of Ktrans, this can be a time-consuming process. Our results show that the average Ktrans calculated from the single largest slice provides statistically similar results that can be easily incorporated into routine clinical practice.

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