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Abstract #1141

Characterization of Invasive Breast Cancer using Quantitative DCE-MRI at 3.0T

Reem Bedair 1 , Martin Graves 2 , Mary McLean 3 , Scott Reid 4 , Roie Manavaki 1 , John Griffiths 3 , Andrew Patterson 2 , and Fiona Gilbert 1

1 University of Cambridge, Department of Radiology, Cambridge, Cambridgeshire, United Kingdom, 2 Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom, 3 Cancer Research UK Cambridge Research Institute, Cambridge, Cambridgeshire, United Kingdom, 4 GE Healthcare, Diagnostic Imaging, Buckingham, Buckinghamshire, United Kingdom

DCE-MRI has proven a promising non-invasive modality for characterizing the pathophysiological microenvironment of tumours. Pharmacokinetic modelling can yield results of tumour-vessel permeability, perfusion and extracellular-extravascular volume fraction. This work exploits the improved spatiotemporal resolution achievable at 3.0T to investigate the relationship between the modelled vascular parameters and their histopathological profile within a cohort of breast cancer patients. Hotspot Ktrans and ve were found to be higher for the more common malignant types. A significant difference was found between hotspot Ktrans and ve in grades 1 and 3 tumours. Our results indicate that Ktrans and ve provide important and independent information concerning tumor biology and microvascular structure that supports the use of these more complex analysis protocols.

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