Abstract #1325
Serum BDNF correlates with connectivity in the (pre)motor hub in the aging human brain: A resting state fMRI study
Karsten Mueller 1 , Harald E Mller 1 , Katrin Arelin 1,2 , Jrgen Kratzsch 3 , Tobias Luck 4 , Steffi Riedel-Heller 4 , Arno Villringer 1,2 , and Matthias L Schroeter 1,2
1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany,
2
Clinic
for Cognitive Neurology, University of Leipzig, Germany,
3
Institute
of Laboratory Medicine, Clinical Chemistry and Molecular
Diagnostics, University of Leipzig, Germany,
4
Institute
of Social Medicine, Occupational Health and Public
Health, University of Leipzig, Germany
We investigated an interaction between plasticity
processes, brain connectivity and healthy aging by
measuring levels of serum BDNF and resting-state fMRI
using eigenvector centrality (EC) mapping. The analysis
revealed a positive correlation between serum BDNF and
EC in premotor and motor regions in elderly subjects in
contrast to young subjects, where we did not detect any
association. This positive relationship between serum
BDNF and EC appears to be specific for elderly subjects.
Our results might indicate that the amount of physical
activity, leading to higher BDNF levels, increases brain
connectivity in (pre)motor areas in healthy aging in
agreement with rodent animal studies.
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