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Abstract #1325

Serum BDNF correlates with connectivity in the (pre)motor hub in the aging human brain: A resting state fMRI study

Karsten Mueller 1 , Harald E Mller 1 , Katrin Arelin 1,2 , Jrgen Kratzsch 3 , Tobias Luck 4 , Steffi Riedel-Heller 4 , Arno Villringer 1,2 , and Matthias L Schroeter 1,2

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2 Clinic for Cognitive Neurology, University of Leipzig, Germany, 3 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany, 4 Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Germany

We investigated an interaction between plasticity processes, brain connectivity and healthy aging by measuring levels of serum BDNF and resting-state fMRI using eigenvector centrality (EC) mapping. The analysis revealed a positive correlation between serum BDNF and EC in premotor and motor regions in elderly subjects in contrast to young subjects, where we did not detect any association. This positive relationship between serum BDNF and EC appears to be specific for elderly subjects. Our results might indicate that the amount of physical activity, leading to higher BDNF levels, increases brain connectivity in (pre)motor areas in healthy aging in agreement with rodent animal studies.

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