Abstract #1326
The sensitivity of olfactory fMRI in quantifying olfactory performance during normal aging
Brittany Martinez 1 , Jianli Wang 1 , Prasanna Karunanayaka 1 , Megha Vasavada 2 , Paul J Eslinger 3 , and Qing X Yang 1,4
1
Radiology, Penn State College of Medicine,
Hershey, PA, United States,
2
Neurology,
UCLA, Los Angeles, CA, United States,
3
Neurology,
Penn State College of Medicine, Hershey, PA, United
States,
4
Neurosurgery,
Penn State College of Medicine, Hershey, PA, United
States
The purpose of this study was to quantitatively evaluate
the effect of aging on olfactory system function using
fMRI and to establish its relationship with olfactory
behavior results. Younger and older subjects
participated in an olfactory fMRI task and were asked to
complete the UPSIT. Younger subjects had significantly
greater activation in the POC and insula during odor
conditions. Age was found to be negatively correlated
with olfactory-related activation, while UPSIT scores
were found to be positively correlated. The results
support that olfactory fMRI is sensitive in the
detection of age-related decline in olfactory function.
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