Longitudinal Analysis of Structural and Functional Connectivity of the Thalamus and Anterior Cingulate Cortex in Mild Traumatic Brain Injury

Mild traumatic brain injury (mTBI) is a significant public healthcare burden that costs the nation billions of dollars each year. Most mTBI patients have normal findings in clinical neuroimaging; however, there are several cognitive and emotional symptoms that can impact patients quality of life. Therefore, we expected to see changes in brain regions associated with higher order functions. The thalamus and anterior cingulate cortex (ACC) are the two main centers of information processing, cognitive and affective functions, and regulation in the brain, and are structurally and functionally connected to each other. Thus, the connections between these regions was investigated longitudinally.

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