Abstract #1414
Axonal alterations at acute stage of a non-impact, blast-induced rat brain injury model by in vivo diffusion tensor imaging
Shiyu Tang 1,2 , Su Xu 1,2 , William L Fourney 3,4 , Ulrich H Leist 3,4 , Julie L Proctor 5,6 , Gary Fiskum 5,6 , and Rao P Gullapalli 1,2
1
Department of Diagnostic Radiology and
Nuclear Medicine, University of Maryland, Baltimore, MD,
United States,
2
Core
for Translational Research in Imaging @ Maryland,
University of Maryland, Baltimore, MD, United States,
3
Department
of Mechanical Engineering, University of Maryland,
Baltimore, Maryland, United States,
4
Center
of Energetics Concepts Development, University of
Maryland, Baltimore, MD, United States,
5
Department
of Anesthesiology, University of Maryland, Baltimore,
MD, United States,
6
Shock,
Trauma, and Anesthesiology Research Center, University
of Maryland, Baltimore, MD, United States
Blast-induced traumatic brain injury (bTBI) is the
hallmark injury of recent wars that includes injuries
associated with underbody blasts caused by vertical
acceleration. However, it is unknown if blast-induced
hyper-acceleration (BIH) alone can cause bTBI in the
absence of mechanical injury. This study investigated
axonal alterations using
in
vivo
DTI
at 2-hours after under-vehicle BIH in rat brains using a
novel recently introduced model of bTBI. Significantly
elevated axial diffusivity, decreased mean and radial
diffusivities were observed in multiple brain regions
which indicated early axonal injury following bTBI. This
unique model of bTBI can provide insights into pure
underbody bTBI.
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