Multi nuclear 3D multiple breath washout imaging with 3 He and 129 Xe using a dual tuned coil

A recently introduced method describes 3D multiple breath washout imaging using hyperpolarized gas MRI. This preliminary study presents a methodology for multiple breath washout imaging with 129-Xe and 3-He using steady-state (bSSFP) imaging and a dual-tuned radiofrequency coil. Comparable functional information was derived from MBW-I datasets from both nuclei, with similar ventilation heterogeneity exhibited by each, despite the intrinsically different physical properties of the two nuclei. In future work, it may be possible to identify sensitivity differences in MBW-I with 3-He and 129-Xe to different physiological processes symptomatic of lung disease.

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