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Abstract #1508

Postprandial Hepatic Glycogen Levels following a Low v High Glycaemic Index Breakfast: A 13 C MRS Study

S Bawden 1,2 , MC Stephenson 3 , K Hunter 4 , M Taylor 5 , L Marciani 1 , PG Morris 2 , IA Macdonald 6 , GP Aithal 1 , and PA Gowland 2

1 NIHR Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom, 2 Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3 Agency for Science, Technology and Research, Singapore, 4 Unilever Discover, Bedfordshire, United Kingdom, 5 Faculty of Human Nutrition, University of Nottingham, United Kingdom, 6 School of Life Sciences, University of Nottingham, United Kingdom

Natural abundance 13 C MRS measurements of liver glycogen levels were acquired from 8 healthy males using a multinuclear surface coil with proton decoupling in a randomized cross over study comparing the postprandial effects of a calorie and macronutrient matched high v low glycaemic index test breakfast. The results from this study showed an immediate increase from fasted levels following both meals which began to decline from 180 minutes for the low GI meal but continued to increase for 300 minutes for the high GI meal

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