2D localized COSY for the quantification of omega-3 PUFA content in oil phantoms and in vivo in rat liver

Fatty liver disease is associated with marked changes in liver lipid composition, i.e. increases in saturated fatty acids and decreases in omega-3 polyunsaturated fatty acids (PUFA). Currently available methods to determine liver lipid composition require a biopsy. The aim of this study was to develop a 2D MRS method for in vivo detection of omega-3 PUFA based on localized correlation spectroscopy (L-COSY). We demonstrate the specific and quantitative detection of omega-3 PUFA with 2D L-COSY in oil phantoms and the feasibility to perform L-COSY in vivo in liver. However, in rat liver omega-3 PUFA content was below the detection limit.

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