Meeting Banner
Abstract #1509

2D localized COSY for the quantification of omega-3 PUFA content in oil phantoms and in vivo in rat liver

Sharon Janssens 1 , Marina D.B. Sabbadini 1 , Klaas Nicolay 1 , and Jeanine J. Prompers 1

1 Biomedical NMR, Eindhoven University of Technology, Eindhoven, Noord-Brabant, Netherlands

Fatty liver disease is associated with marked changes in liver lipid composition, i.e. increases in saturated fatty acids and decreases in omega-3 polyunsaturated fatty acids (PUFA). Currently available methods to determine liver lipid composition require a biopsy. The aim of this study was to develop a 2D MRS method for in vivo detection of omega-3 PUFA based on localized correlation spectroscopy (L-COSY). We demonstrate the specific and quantitative detection of omega-3 PUFA with 2D L-COSY in oil phantoms and the feasibility to perform L-COSY in vivo in liver. However, in rat liver omega-3 PUFA content was below the detection limit.

This abstract and the presentation materials are available to members only; a login is required.

Join Here