A 7 Day Low v High Glycaemic Index Diet Reduces Liver Fat Content
S Bawden 1,2 , M Stephenson 3 , K Hunter 4 , M Taylor 5 , PG Morris 2 , L Marciani 1 , IA Macdonald 6 , GP Aithal 1 , and PA Gowland 2
NIHR Nottingham Digestive Diseases
Biomedical Research Unit, Nottingham University
Hospitals NHS Trust and University of Nottingham,
Nottingham, United Kingdom,
Peter Mansfield Imaging Centre, University of
Nottingham, Nottingham, United Kingdom,
for Science, Technology and Research, Singapore,
Discover, Bedfordshire, United Kingdom,
of Human Nutrition, University of Nottingham, United
of Life Sciences, University of Nottingham, United
MRS measurements of hepatic fat fractions were acquired
from 8 healthy males in a randomized crossover study.
Subjects attended test days before and after a 7 day
high v low glycaemic index diet. During the test visit,
subjects were scanned at baseline following an overnight
fast and again 360 minutes after a test meal. Results
showed that liver lipid levels were increased following
the high compared to low glycaemic index diet which was
sustained throughout the test day. These results may be
relevant to the prevention and treatment of NAFLD.
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