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Abstract #1510

A 7 Day Low v High Glycaemic Index Diet Reduces Liver Fat Content

S Bawden 1,2 , M Stephenson 3 , K Hunter 4 , M Taylor 5 , PG Morris 2 , L Marciani 1 , IA Macdonald 6 , GP Aithal 1 , and PA Gowland 2

1 NIHR Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom, 2 Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3 Agency for Science, Technology and Research, Singapore, 4 Unilever Discover, Bedfordshire, United Kingdom, 5 Faculty of Human Nutrition, University of Nottingham, United Kingdom, 6 School of Life Sciences, University of Nottingham, United Kingdom

Localized 1 H MRS measurements of hepatic fat fractions were acquired from 8 healthy males in a randomized crossover study. Subjects attended test days before and after a 7 day high v low glycaemic index diet. During the test visit, subjects were scanned at baseline following an overnight fast and again 360 minutes after a test meal. Results showed that liver lipid levels were increased following the high compared to low glycaemic index diet which was sustained throughout the test day. These results may be relevant to the prevention and treatment of NAFLD.

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