Abstract #1911
Improving Tumor Targeting and MRI of Pancreatic Cancer Using IGF-1R Targeted "Stealth" Iron Oxide Nanoparticles
Yuancheng Li 1,2 , Hongyu Zhou 3 , Run Lin 1,2 , Liya Wang 1,2 , Jing Huang 1,2 , Hui Wu 1,2 , Lily Yang 3 , and Hui Mao 1,2
1
Laboratory of Functional-Molecular Imaging
and Nanomedicine, Emory University School of Medicine,
Atlanta, Georgia, United States,
2
Department
of Radiology and Imaging Sciences, Emory University
School of Medicine, Atlanta, Georgia, United States,
3
Department
of Surgery, Emory University School of Medicine,
Atlanta, Georgia, United States
Biomarker-targeted pancreatic tumor imaging has been
investigated by MRI using the anti-biofouling iron oxide
nanoparticle (IONP) previously developed in our group.
This nanomaterial demonstrated an excellent
anti-biofouling effect to prevent the formation of
protein corona and the non-specific cellular uptake. As
a consequence of the excellent anti-biofouling property,
PEG-b-AGE coated IONP conjugated with targeting ligands
showed significantly improved targeting specificity and
efficiency by reducing off-target and non-specific
interactions with biological media. After systemic
administration of IGFR targeted IGF-IONP and
non-targeted BSA-IONP, in vivo MRI showed 44% and 21%
signal intensity drop in pancreatic tumor.
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