Abstract #1912
Paramagnetic micelles targeting VCAM-1 receptors for imaging inflamed endothelium by MRI
Amerigo Pagoto 1 , Rachele Stefania 2 , Francesca Garello 2 , Francesca Arena 2 , Giuseppe Digilio 3 , Silvio Aime 2 , and Enzo Terreno 2
1
University of Torino, Torino, Italy,
2
University
of Torino, Italy,
3
University
of Eastern Piedmont, Italy
Imaging inflammation is still a hot topic for its
relevance in both diagnosis and therapeutic fields. To
overcome the poor sensitivity in the detection of MRI
contrast agents, we target the intravascular
inflammation-associated receptors VCAM-1 (Vascular Cell
Adhesion Molecule-1) that are involved in the
recruitment of immune cells from blood to the
inflammation site. To further increase sensitivity,
micellar nanoparticles containing a high number of
Gd(III) complexes were prepared. Such micelles, which
exposed the MRI agents, a specific peptide targeting
VCAM-1, and a fluorescent dye for histological
validation, were successfully tested on mouse models of
peripheral, and brain inflammation.
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