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Abstract #1912

Paramagnetic micelles targeting VCAM-1 receptors for imaging inflamed endothelium by MRI

Amerigo Pagoto 1 , Rachele Stefania 2 , Francesca Garello 2 , Francesca Arena 2 , Giuseppe Digilio 3 , Silvio Aime 2 , and Enzo Terreno 2

1 University of Torino, Torino, Italy, 2 University of Torino, Italy, 3 University of Eastern Piedmont, Italy

Imaging inflammation is still a hot topic for its relevance in both diagnosis and therapeutic fields. To overcome the poor sensitivity in the detection of MRI contrast agents, we target the intravascular inflammation-associated receptors VCAM-1 (Vascular Cell Adhesion Molecule-1) that are involved in the recruitment of immune cells from blood to the inflammation site. To further increase sensitivity, micellar nanoparticles containing a high number of Gd(III) complexes were prepared. Such micelles, which exposed the MRI agents, a specific peptide targeting VCAM-1, and a fluorescent dye for histological validation, were successfully tested on mouse models of peripheral, and brain inflammation.

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