Abstract #1913
Functional Brain Mapping in ADHD Rats using Manganese-enhanced MRI
Chieh-Yin Chang 1 , Chi-Ru Lai 1 , Bor-Show Tzang 2 , Vincent Chin-Hung Chen 3 , Yeu-Sheng Tyan 1,4 , and Jun-Cheng Weng 1,4
1
School of Medical Imaging and Radiological
Sciences, Chung Shan Medical University, Taichung,
Taiwan,
2
Institute
of Biochemistry and Biotechnology, Chung Shan Medical
University, Taichung, Taiwan,
3
Department
of Psychiatry, Chung Shan Medical University Hospital,
Taichung, Taiwan,
4
Department
of Medical Imaging, Chung Shan Medical University
Hospital, Taichung, Taiwan
The spontaneously hypertensive rat (SHR) is the
best-validated animal model of attention-deficit
hyperactivity disorder (ADHD) based on behavioral,
genetic, and neurobiological data. The symptoms of this
common disorder include difficulty controlling behavior
and over-activity. Manganese-enhanced MRI (MEMRI) uses
manganese ion (Mn2+) as the contrast agents by
shortening the spin-lattice relaxation time constant
(T1) and entering the voltage-gated calcium channels in
active neurons. It enables visualization of neuronal
tracks, and enhance the capacity of MRI to provide
functional information of the localization of brain
activity. In the study, we tried to establish a working
protocol to map the motor cortex of ADHD rats, and
compared the functional brain mapping between ADHD and
normal Wistar-Kyoto (WKY) rats by MEMRI method. In the
results, we have mapped ADHD motor cortex using MEMRI
and have shown the difference of the manganese enhanced
cortical and thalamic regions between ADHD and WKY rats.
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