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Abstract #1913

Functional Brain Mapping in ADHD Rats using Manganese-enhanced MRI

Chieh-Yin Chang 1 , Chi-Ru Lai 1 , Bor-Show Tzang 2 , Vincent Chin-Hung Chen 3 , Yeu-Sheng Tyan 1,4 , and Jun-Cheng Weng 1,4

1 School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 2 Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan, 3 Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan, 4 Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

The spontaneously hypertensive rat (SHR) is the best-validated animal model of attention-deficit hyperactivity disorder (ADHD) based on behavioral, genetic, and neurobiological data. The symptoms of this common disorder include difficulty controlling behavior and over-activity. Manganese-enhanced MRI (MEMRI) uses manganese ion (Mn2+) as the contrast agents by shortening the spin-lattice relaxation time constant (T1) and entering the voltage-gated calcium channels in active neurons. It enables visualization of neuronal tracks, and enhance the capacity of MRI to provide functional information of the localization of brain activity. In the study, we tried to establish a working protocol to map the motor cortex of ADHD rats, and compared the functional brain mapping between ADHD and normal Wistar-Kyoto (WKY) rats by MEMRI method. In the results, we have mapped ADHD motor cortex using MEMRI and have shown the difference of the manganese enhanced cortical and thalamic regions between ADHD and WKY rats.

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