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Abstract #1914

Manganese Accumulations in Brain and Toenails reflect Different Time Periods of Exposure

Chien-Lin Yeh 1,2 , Eric Ward 1 , Sandy Snyder 1 , Frank Rosenthal 1 , and Ulrike Dydak 1,2

1 School of Health Sciences, Purdue University, West Lafayette, Indiana, United States, 2 Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States

High exposure to manganese (Mn) causes motor impairments closely resembling Parkinsons disease. Using R1 relaxation rate mapping we investigated the relationship between Mn deposition in the brain of welders with Mn accumulation in toenails. A significant correlation was found between R1 and Mn exposure in the past 3 months, but no correlation was found between toenail Mn and R1. Since toenail Mn is known to best reflect exposure 7-12 months ago, our results demonstrate that R1 in certain brain regions and toenail Mn accumulation may both serve as biomarkers of exposure to Mn, reflecting different time periods of exposure.

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