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Abstract #1915

Adult Neurogenesis and Olfactory Activity Regulate Olfactory Bulb Volume

Nikorn Pothayee 1 , Diana Cummings 2 , Timothy Schoenfeld 3 , Heather Cameron 3 , Leonardo Belluscio 2 , and Alan Koretsky 1

1 Laboratory of functional and molecular imaging, NINDS, NIH, Bethesda, MD, United States, 2 Developmental neural plasticity section, NINDS, NIH, Bethesda, MD, United States, 3 Neuroplasticity Section, NIMH, NIH, Bethesda, MD, United States

Olfactory bulb displays remarkable plasticity and its volume changes have been implicated in many CNS pathologies such as Alzheimers and Parkinsons diseases. Understanding factors that play role in regulating the OB and its size may yield insights into the OB plasticity. In this work, we utilize longitudinal cellular MRI in combination with transgenic animal model of adult neurogenesis to study interplaying effects of olfactory input level and neurogenesis on the dynamic volume changes of the olfactory bulb.

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