Meeting Banner
Abstract #1916

Distinction between pro and anti-inflammatory macrophages using MRI relaxometry and quantitative susceptibility mapping

Wassef Khaled 1 , Benjamin Leporq 1 , Jing Hong Wan 1 , Philippe Garteiser 1 , Simon Auguste Lambert 1 , Nathalie Mignet 2 , Bich-Thuy Doan 2 , Simona Manta 2 , Sophie Lotersztajn 1 , and Bernard Edgar Van Beers 1

1 Center of research on inflammation, Paris 7 University; INSERM U1044, Paris, France, 2 Chemical, Genetic and Imaging Pharmacology Laboratory; CNRS UMR 8151; INSERM U1022, Faculty of Pharmacy, Paris Descartes University, Sorbonne Paris Cit, Chimie-ParisTech, Paris, France

This work aims at distinguishing pro and anti-inflammatory (M1 and M2) macrophages with relaxometry and QSM using the degree of phagocytosis of gadolinium liposomes and superparamagnetic iron oxide particles as imaging biomarker. At relaxometry and QSM, M1 macrophages showed higher R2*and susceptibility, indicating higher particle uptake, as confirmed by confocal microscopy. These results show that it is feasible to distinguish between M1 and M2 macrophages with relaxometry and QSM, making phagocytosis of magnetic particles a potential MRI biomarker of inflammation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here