Abstract #1916
Distinction between pro and anti-inflammatory macrophages using MRI relaxometry and quantitative susceptibility mapping
Wassef Khaled 1 , Benjamin Leporq 1 , Jing Hong Wan 1 , Philippe Garteiser 1 , Simon Auguste Lambert 1 , Nathalie Mignet 2 , Bich-Thuy Doan 2 , Simona Manta 2 , Sophie Lotersztajn 1 , and Bernard Edgar Van Beers 1
1
Center of research on inflammation, Paris 7
University; INSERM U1044, Paris, France,
2
Chemical,
Genetic and Imaging Pharmacology Laboratory; CNRS UMR
8151; INSERM U1022, Faculty of Pharmacy, Paris Descartes
University, Sorbonne Paris Cit, Chimie-ParisTech,
Paris, France
This work aims at distinguishing pro and
anti-inflammatory (M1 and M2) macrophages with
relaxometry and QSM using the degree of phagocytosis of
gadolinium liposomes and superparamagnetic iron oxide
particles as imaging biomarker. At relaxometry and QSM,
M1 macrophages showed higher R2*and susceptibility,
indicating higher particle uptake, as confirmed by
confocal microscopy. These results show that it is
feasible to distinguish between M1 and M2 macrophages
with relaxometry and QSM, making phagocytosis of
magnetic particles a potential MRI biomarker of
inflammation.
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