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Abstract #1935

Initial Evaluation of an MR-Hyperthermia Activated Thermosensitive Drug Delivery System

Matthew Tarasek 1 , Amanda Aleong 2,3 , Jinzi Zheng 2,3 , Yannan Dou 4 , Christine Allen 3,4 , David Jaffray 3,4 , Tom Foo 1 , and Desmond T.B. Yeo 1

1 MRI, GE Global Research, Niskayuna, NY, United States, 2 Princess Margaret Cancer Centre, Toronto, Canada, 3 Techna Institute, University Health Network, Toronto, Canada, 4 University of Toronto, Toronto, Canada

Current innovations in the field of advanced drug delivery are focused on the development of new systems that can (i) trigger drug release at the tumor sites, (ii) avoid drug deposition in non-target tissues, and (iii) allow for quantitative measurement of drug dose to the target tissue. Here we report a pilot evaluation of a novel MR image-guided radiofrequency (RF) hyperthermia-mediated drug delivery platform. Results indicate that the MR body coil provides adequate image quality for monitoring drug release in the current setup, despite its inherent limitations in image acquisition speed and SNR when compared to surface-coil arrays.

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