Abstract #1936
Functionalized Mesoporous Silica Iron Oxide Nanoparticles for Thermal Therapy and T 1 Contrast
Hattie L. Ring 1,2 , Katie R. Hurley 2 , Michael Etheridge 3,4 , Jinjin Zhang 1,5 , Nathan D. Klein 2 , Connie Chung 3,4 , Qi Shao 4 , John C. Bischof 3,4 , Christy L. Haynes 2 , and Michael Garwood 1,6
1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States,
2
Chemistry,
University of Minnesota, Minneapolis, MN, United States,
3
Mechanical
Engineering, University of Minnesota, Minneapolis, MN,
United States,
4
Biomedical
Engineering, University of Minnesota, Minneapolis, MN,
United States,
5
Physics,
University of Minnesota, Minneapolis, MN, United States,
6
Radiology,
University of Minnesota, Minneapolis, MN, United States
Iron oxide nanoparticles (IONPs) have great potential as
diagnostic and therapeutic agents in cancer and other
diseases; however, their utility is limited by
biological aggregation and a short T
2
. We
implement the incorporation of a functionalized
mesoporous silica (ms) shell combined with sweep imaging
with Fourier transform MRI. This enables the practical
use of IONPs as a T
1
contrast
agent
in
vitro
and
in
vivo
, which is demonstrated in lymph node carcinoma
of prostate cells and tumors. Colloidal stability and
minimal non-specific cell uptake allowed for effective
heating in biological suspensions and strong signal
enhancement in MRI
in
vivo
.
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