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Abstract #1936

Functionalized Mesoporous Silica Iron Oxide Nanoparticles for Thermal Therapy and T 1 Contrast

Hattie L. Ring 1,2 , Katie R. Hurley 2 , Michael Etheridge 3,4 , Jinjin Zhang 1,5 , Nathan D. Klein 2 , Connie Chung 3,4 , Qi Shao 4 , John C. Bischof 3,4 , Christy L. Haynes 2 , and Michael Garwood 1,6

1 Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2 Chemistry, University of Minnesota, Minneapolis, MN, United States, 3 Mechanical Engineering, University of Minnesota, Minneapolis, MN, United States, 4 Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States, 5 Physics, University of Minnesota, Minneapolis, MN, United States, 6 Radiology, University of Minnesota, Minneapolis, MN, United States

Iron oxide nanoparticles (IONPs) have great potential as diagnostic and therapeutic agents in cancer and other diseases; however, their utility is limited by biological aggregation and a short T 2 . We implement the incorporation of a functionalized mesoporous silica (ms) shell combined with sweep imaging with Fourier transform MRI. This enables the practical use of IONPs as a T 1 contrast agent in vitro and in vivo , which is demonstrated in lymph node carcinoma of prostate cells and tumors. Colloidal stability and minimal non-specific cell uptake allowed for effective heating in biological suspensions and strong signal enhancement in MRI in vivo .

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