Abstract #1937
Quantitative treatment response mapping in asthma patients using 3 He ventilation MRI
Felix C Horn 1 , Helen Marshall 1 , Richard Kay 2 , Christopher E Brightling 3 , Juan Parra-Robles 1 , and Jim M Wild 1
1
Academic Radiology, Sheffield University,
Sheffield, South Yorkshire, United Kingdom,
2
Novartis,
Switzerland,
3
University
of Leicester, United Kingdom
Sensitive regional methods to assess efficacy of
respiratory therapeutics are urgently needed. A method
using hyperpolarized 3He ventilation imaging is
introduced to calculate quantitative treatment response
maps. Ventilation images from before and after
bronchodilator treatment are used to quantify
ventilation changes and are masked by a baseline
variability calculated from two ventilation images
acquired before treatment. The technique is compared to
percentage ventilated volume (%VV) and forced expiratory
volume (FEV1). In this cohort all tests showed
significant differences before and after treatment,
nevertheless TRM displayed a tighter clustering and
clearer separation of positive from negative response.
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