Meeting Banner
Abstract #1937

Quantitative treatment response mapping in asthma patients using 3 He ventilation MRI

Felix C Horn 1 , Helen Marshall 1 , Richard Kay 2 , Christopher E Brightling 3 , Juan Parra-Robles 1 , and Jim M Wild 1

1 Academic Radiology, Sheffield University, Sheffield, South Yorkshire, United Kingdom, 2 Novartis, Switzerland, 3 University of Leicester, United Kingdom

Sensitive regional methods to assess efficacy of respiratory therapeutics are urgently needed. A method using hyperpolarized 3He ventilation imaging is introduced to calculate quantitative treatment response maps. Ventilation images from before and after bronchodilator treatment are used to quantify ventilation changes and are masked by a baseline variability calculated from two ventilation images acquired before treatment. The technique is compared to percentage ventilated volume (%VV) and forced expiratory volume (FEV1). In this cohort all tests showed significant differences before and after treatment, nevertheless TRM displayed a tighter clustering and clearer separation of positive from negative response.

This abstract and the presentation materials are available to members only; a login is required.

Join Here