A method to obtain 2D high resolution MRS under inhomogeneous magnetic fields

The inherent heterogeneity of the samples or living organisms can lead to magnetic field fluctuations and losses of local homogeneity. Intermolecular multiple quantum coherences (iMQCs) can be used to obtain high resolution magnetic resonance spectroscopy (MRS) under field inhomogeneity, while intrinsic low signal-to-noise ratio (SNR) of iMQC signals hampers their practical applications. Here, a pulse sequence is designed to acquire 2D high-resolution spectra under inhomogeneous fields with high SNRs. The high-resolution chemical-shift difference information and J-coupling splitting information are separately shown in two independent dimensions.

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