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Abstract #2033

MEMRI and BOLD analyses of the olfactory perception system in response to odorant stimuli in mice

Hirotsugu Funatsu 1 , Sosuke Yoshinaga 1 , Haruna Goto 1 , Makoto Hirakane 1 , Shigeto Iwamoto 1 , and Hiroaki Terasawa 1

1 Department of Structural BioImaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

Odors are chemical signals that regulate a wide range of social and sexual behaviors in animals. The aim of this study is to reveal the neural circuitry from the olfactory bulb to the higher-order brain areas that recognize and discriminate odors in mice. Based on the real-time BOLD and longer time-scale MEMRI techniques, the muscone odor induced signal enhancement in the peripheral olfactory bulb, where chemical signals from the olfactory epithelium are transmitted. The BOLD signal-enhanced regions coincided with the regions identified by an immunohistochemical analysis. We successfully visualized the odor-evoked activation by the combined use of BOLD and MEMRI.

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