Abstract #2033
MEMRI and BOLD analyses of the olfactory perception system in response to odorant stimuli in mice
Hirotsugu Funatsu 1 , Sosuke Yoshinaga 1 , Haruna Goto 1 , Makoto Hirakane 1 , Shigeto Iwamoto 1 , and Hiroaki Terasawa 1
1
Department of Structural BioImaging, Faculty
of Life Sciences, Kumamoto University, Kumamoto, Japan
Odors are chemical signals that regulate a wide range of
social and sexual behaviors in animals. The aim of this
study is to reveal the neural circuitry from the
olfactory bulb to the higher-order brain areas that
recognize and discriminate odors in mice. Based on the
real-time BOLD and longer time-scale MEMRI techniques,
the muscone odor induced signal enhancement in the
peripheral olfactory bulb, where chemical signals from
the olfactory epithelium are transmitted. The BOLD
signal-enhanced regions coincided with the regions
identified by an immunohistochemical analysis. We
successfully visualized the odor-evoked activation by
the combined use of BOLD and MEMRI.
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